The HIV epidemic disproportionately affects the Southern U.S., where 51% of new HIV diagnoses occurred in 2013. Despite substantial progress along the continuum of care, HIV remains a major health concern in the South, particularly for young, Black gay and bisexual men, other men who have sex men (MSM), and transgender women. Our new publication “HIV Prevention in the South: Reducing Stigma, Increasing Access” presents four strategic elements for preventing the further spread of HIV among vulnerable populations in the South, and suggests a more hopeful future for reducing the HIV epidemic.