In this talk from the 2022 Advancing Excellence in Transgender Health Care Conference, Steph deNormand and Mason Dunn discuss engaging leadership in creating organizational change. By the end of this talk, you will be able to Understand at least three markers of a more inclusive environment for trans and gender diverse staff, clients, patients, and community members, recognize the necessity to involve all levels of and positions in an organization to build system-wide change, consider changes to workforce development to attract transgender and gender diverse applicants and employees, and be able to apply the case example of Fenway Health to one’s own place of work, and develop at least two next steps for organizational change.