HCV and HIV are overlapping epidemics with serious clinical implications for infected patients and health centers are poised to prevent and treat these viral infections by understanding the implications of comorbidity and by creating a welcoming environment for those at risk for, previously infected, or currently living with one or both diseases. This publication, a collaboration of the National Nurse-Led Care Consortium and the National LGBTQIA+ Health Education Center, explores the link between HCV and HIV, with particular emphasis on considerations for community-based primary care providers.