The Fenway Health Transgender Health Program (THP) produced these protocols for clinicians in primary care settings to best serve their Transgender and Gender Diverse (TGD) patients. The mission of Fenway Health is to enhance the wellbeing of the lesbian, gay, bisexual, and transgender communities and all people in our neighborhood and beyond. As part of that larger mission, the THP seeks to promote and support knowledgeable and comprehensive care to TGD persons in an environment that is comfortable, safe, and affirming.