Lesbian, gay, bisexual, and transgender individuals continue to face stigma and discrimination even though social acceptance is improving. This stigma and discrimination can result in negative experiences that combine with lack of access to culturally-affirming and informed health professionals to result in multiple health disparities for LGBT populations. Therefore, there is an urgent need to provide inclusive, high-quality health services to LGBT people so they can achieve the highest possible level of health. This document reviews LGBT concepts and demographics, discusses health disparities affecting LGBT groups, and outlines steps that clinicians, health centers, and other health care organizations can take to provide patient-centered care for LGBT people.