This publication was designed as a companion resource to Ready, Set, Go! Guidelines and Tips for Collecting Patient Data on Sexual Orientation and Gender Identity (SOGI) to explain the importance of SOGI data collection to identify and address the unique needs of sexual and gender minority patient populations, with special consideration for culturally and linguistically diverse patients who are part of LGBTQIA+ communities. This guide will help healthcare staff to identify procedures to translate and adapt SOGI data collection questions and patient education materials for multilingual patient populations accurately and affirmatively, with considerations for Spanish-speaking LGBTQIA+ patients as an example. The recommendations in this publication will assist health teams in planning next actions to implement culturally and linguistically affirming practices that are community informed and integrated throughout the health experiences of multilingual, multiethnic, and racially diverse patients.